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Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells

Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells

June 30, 2025 Category: Blog

Abstract Neuroglobin (NGB) is a hexacoordinated hemeprotein mainly expressed in neurons.Following its upregulation and mitochondrial localization, NGB plays a pro-survival role against neuronal stress.Previously, we built a stable NGB-FLAG-overexpressing neuroblastoma cell line and showed that NGB promotes autophagy and localizes in autophagolysoso

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Shared and independent roles of CGRP and PACAP in migraine pathophysiology

June 30, 2025 Category: Blog

Abstract The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate fiesta® Coastal cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis.Both are vasodilatory peptides that can cause migraine-like attacks when infused into people and migraine-like symptoms when injected into rodents.In thi

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Ski Mountaineering: Perspectives on a Novel Sport to Be Introduced at the 2026 Winter Olympic Games

June 30, 2025 Category: Blog

Ski mountaineering is a rapidly Knitwear growing winter sport that involves alternately climbing and descending slopes and various racing formats that differ in length and total vertical gain, as well as their distribution of downhill and uphill sections.In recent years, both participation in and media coverage of this sport have increased dramatic

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Observation of Soliton Molecules in a Robust All PM Mode-Locked Fiber Laser With Nonreciprocal Phase Bias

June 30, 2025 Category: Blog

We report Knitwear the first experimental observation, to the best of our knowledge, of soliton molecules in a robust all polarization-maintaining (PM) mode-locked fiber laser with a nonreciprocal phase bias that results in a low self-starting threshold and stable mode locking.Through elaborately tuning the waveplate in the cavity, calibrating the

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